Safety evaluation of timber structures through probabilistic analysis

This work presents a procedure for the use of probabilistic modelling techniques in the assessment of safety parameters of existing timber structures, when influenced by two types of actions. The parameters of the models have been defined as probabilistic variables, and Monte Carlo simulation technique was taken into account for safety evaluation. The case study here examined concerns four king post trusses on which a safety evaluation method was conducted to determine a target reliability index. Since the structures presented a high level of deterioration, a model considering the variation of the residual cross-section and the influence of environment in resistance was taken into account. Time dependent deterioration models have also been considered. With the results given by the different used models, it was possible to obtain probabilities of failure and respective reliability indices, as well as time evolution deterioration curves for a deteriorated historical structure.The financial support of the Portuguese Science Foundation (Fundacao de Ciencia e Tecnologia, FCT), through project PTDC/66527-2006, is gratefully acknowledged. The third author acknowledges the support of FCT through research centre UNIC

Improving order-picking operations with precedence constraints through efficient storage location assignment: evidence from a retail company

This paper is inspired by a manual picking retail company where shape and weight constraints affect the order-picking process. We proposed an alternative clustering similarity index that considers the similarity, the weight and the shape of products. This similarity index was further incorporated in a storage allocation heuristic procedure to set the location of the products. We test the procedure in a retail company that supplies over 191 stores, in Northern Portugal. When comparing the strategy currently used in the company with this procedure, we found out that our approach enabled a reduction of up to 40% on the picking distance; a percentage of improvement that is 32% higher than the one achieved by applying the Jaccard index, a similarity index commonly used in the literature. This allows warehouses to save time and work faster.info:eu-repo/semantics/publishedVersio

The rediscovery of Caulerpa prolifera in Ria Formosa, Portugal, 60 years after the previous record

The westernmost occurrence of Caulerpa prolifera on the Atlantic European coast has been accepted in recent decades, to be Huelva province, southern Spain. In April 2011, this species was found in Ria Formosa, southern Portugal, extending its westernmost limit along the Iberian Peninsula coastline. In the course of research into this species it was discovered that this alga had been found in Ria Formosa in the 19th century by the naturalist Welwitsch and subsequently in the 1930s by others but it was never found in the many field studies conducted in Ria Formosa during the past few decades. The species had therefore either become extinct in the area or persisted as a cryptic undetected stage. In order to investigate the source of colonization and to verify the genetic identity, a partial cpDNA region (tufA gene) was sequenced. Comparisons of nucleotide similarity in sequences from the Ria Formosa and from populations of the Atlantic and Mediterranean confirmed the Caulerpa prolifera identification and gave clues about a possible origin of this population as deriving from expansion of a Mediterranean source rather than one from the western Atlantic

Applying Goldratt’s Framework to the Banking System

This paper describes the major elements of the Goldratt’s framework – the Theory of Constraints (TOC) – in the banking sector, and examines the factors involved in the decision to adopt the TOC by companies in this sector. Through a deep literature review, analyzing similar cases that apply the Goldratt’s framework in services and in manufacturing and the severalviews of its components, we aim at formulating a framework specifically for the banking system.The study uses a qualitative methodology supported by the information extracted from reality as it is framed in a multicase study model. As part of the quantitative approach, we test several research hypotheses raised from the review of existing studies in the area.The main factors that influence the decision to adopt the TOC are the nature and the characteristics of the banking service, the attitude towards change, the leadership and the commitment of the entire institution.By using the Goldratt’s approach outlined in this article, through the location of the constraints and develop practical measurement to facilitate the banking process improvements, banks can improve resource utilization, revenues and employee satisfaction

Alternative models for the calculation of the RMR and Q indexes for granite rock masses

Empirical classification systems like the RMR and Q are often used in current practice of geotechnical structures design built in rock masses. They allow obtaining an overall description of the rock mass and the calculation, through analytical solutions, of strength and deformability parameters which are determinant in design. To be applied these systems need a set of geomechanical information that may not be available or can be difficult to obtain. In this work it is intended to develop new alternative regression models for the calculation of the RMR and Q indexes using less data than the original formulations and keeping a high accuracy level. It is also intended to have an insight of which parameters are the most important for the prediction of the indexes and in the rock masses behaviour. This study was carried out applying Data Mining techniques to a database of the empirical classification systems applications in a granite rock mass. Data Mining is a relatively new area of computer science which concerns with automatically find, simplify and summarize patterns and relationships within large databases. The used Data Mining techniques were the multiple regression and artificial neural networks. The developed models are able to predict the two geomechanical indexes using less information that in the original formulations with a good predictive capacity.Fundação para a Ciência e a Tecnologia (FCT) - projecto POCI/ECM/57495/2004 "Geotechnical Risk in Tunnels for High Speed Trains

Structural behaviour analysis of Faria Guimarães station

No presente estudo efectua-se a modelação e análise do comportamento estrutural da estação Faria Guimarães, do Metro do Porto. A estação é constituída por um cruzamento oblíquo de duas grandes galerias executadas através do método SEM/NATM. A obra é de elevada complexidade devido aos condicionamentos geométricos da estação e obras adjacentes, à grande heterogeneidade do maciço e à ocupação intensa da superfície. A análise do comportamento estrutural da estação foi realizada recorrendo a modelos numéricos 2D e 3D, bem como a resultados obtidos com a observação da estação.In present paper the modelling and structural behaviour analysis of the Faria Guimarães station, of Metro do Porto, is presented. The station includes the inclined intersection of two large galleries executed through SEM/NATM method. The work is highly complex due to geometric limitations of the station and adjacent works, the heterogeneity of the rock mass and the dense occupation at surface. The structural behaviour analysis of the station was performed using 2D and 3D numerical models, as well as results obtained through the observation of the station.Fundação para a Ciência e Tecnologia (FCT) - Projecto POCI/ECM/57495/2004, intitulado Geotechnical Risk in Tunnels for High Speed Trains

Anti-saccades in early stages of multiple sclerosis

Eye movements disability is common finding in multiple sclerosis but the exact stage at which changes are visible is not clear. The aim of study was to assess if anti-saccade planning and execution are altered at early stages of the disease.TEM-All with the Mutiple Sclerosis, Braga, Portugalinfo:eu-repo/semantics/publishedVersio

In situ crosslinked electrospun gelatin nanofibers for skin regeneration

Due to its intrinsic similarity to the extracellular matrix, gelatin electrospun nanofibrous meshes are promising scaffold structures for wound dressings and tissue engineering applications. However, gelatin is water soluble and presents poor mechanical properties, which generally constitute relevant limitations to its applicability. In this work, gelatin was in situ crosslinked with 1,4-butanediol diglycidyl ether (BDDGE) at different concentrations (2, 4 and 6 wt%) and incubation time-points (24, 48 and 72 h) at 37 °C. The physico-chemical and biological properties of BDDGE-crosslinked electrospun gelatin meshes were investigated. Results show that by changing the BDDGE concentration it is possible to produce nanofibers crosslinked in situ with well-defined morphology and modulate fiber size and mechanical properties. Crosslinked gelatin meshes show no toxicity towards fibroblasts, stimulating their adhesion, proliferation and synthesis of new extracellular matrix, thereby indicating the potential of this strategy for skin tissue engineering.info:eu-repo/semantics/acceptedVersio

In vivo confocal Raman spectroscopy and molecular dynamics analysis of penetration of retinyl acetate into stratum corneum

Objective The purpose of this study is to elucidate the behavior of retinyl acetate in penetrating human skin without the presence of enhancers by using confocal Raman spectroscopy and molecular dynamics simulation. Methods In this study, in vivo confocal Raman spectroscopy was combined with molecular dynamics simulation to investigate the transdermal permeation of the aqueous suspension of retinyl acetate. Results Permeation was measured after 30 min, and retinyl acetate was found up to 20 m deep inside the stratum corneum. The delivery of retinyl acetate inside a skin membrane model was studied by molecular dynamics. The membrane model that was used represented normal young skin containing a lipid bilayer with 25% ceramide, 36% fatty acid, 30% cholesterol, and 6% cholesterol sulfate. Conclusion Spectroscopy data indicate that retinyl acetate permeates into the stratum corneum. Molecular dynamics data showed that retinyl acetate permeates in the membrane model and that their final location is deep inside the lipid bilayer. We showed, for the first time, a correlation between Raman permeation data and computational data.C.A. Telléz S. would like to thank Capes/Brazil (88881.068140/2014-01 and 88887.125253/2015-00) for the grant. A.M. Cavaco-Paulo thanks Fapesp/Brazil (2014/05975-2) for the grant

The dynamics of stress: a longitudinal MRI study of rat brain structure and connectome

Stress is a well-established trigger for a number of neuropsychiatric disorders, as it alters both structure and function of several brain regions and its networks. Herein, we conduct a longitudinal neuroimaging study to assess how a chronic unpredictable stress protocol impacts the structure of the rat brain and its functional connectome in both high and low responders to stress. Our results reveal the changes that stress triggers in the brain, with structural atrophy affecting key regions such as the prelimbic, cingulate, insular and retrosplenial, somatosensory, motor, auditory and perirhinal/entorhinal cortices, the hippocampus, the dorsomedial striatum, nucleus accumbens, the septum, the bed nucleus of the stria terminalis, the thalamus and several brain stem nuclei. These structural changes are associated with increasing functional connectivity within a network composed by these regions. Moreover, using a clustering based on endocrine and behavioural outcomes, animals were classified as high and low responders to stress. We reveal that susceptible animals (high responders) develop local atrophy of the ventral tegmental area and an increase in functional connectivity between this area and the thalamus, further spreading to other areas that link the cognitive system with the fight-or-flight system. Through a longitudinal approach we were able to establish two distinct patterns, with functional changes occurring during the exposure to stress, but with an inflection point after the first week of stress when more prominent changes were seen. Finally, our study revealed differences in functional connectivity in a brainstem-limbic network that distinguishes resistant and susceptible responders before any exposure to stress, providing the first potential imaging-based predictive biomarkers of an individual's resilience/vulnerability to stressful conditions.This work is part of the Sigma project with the reference FCT-ANR/NEU-OSD/ 0258/2012 co-financed by the French public funding agency ANR (Agence National pour la Recherche, APP Blanc International II 2012), the Portuguese FCT (Fundação para a Ciência e Tecnologia) and by the Portuguese North Regional Operational Program (ON.2 – O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER) as well as the Projecto Estratégico co-funded by FCT (PEst-C/SAU/LA0026-/2013) and the European Regional Development Fund COMPETE (FCOMP-01-0124-FEDER-037298). DAB and AN were funded by grants from FCT-ANR/NEU-OSD/0258/2012. RM is supported by the FCT fellowship grant with the reference PDE/BDE/113604/2015 from the PhDiHES program; AC was supported by a grant from the foundation NRJ. PM was funded by Fundação Calouste Gulbenkian (Portugal; ‘Better mental health during ageing based on temporal prediction of individual brain ageing trajectories (TEMPO)’), Grant Number P-139977. We thank Drs Patrício Costa and Pedro Moreira for support on the various statistical analyses.info:eu-repo/semantics/publishedVersio